An aromatase inhibitor and tamoxifen decrease plasma levels of o,p'-DDT and its metabolites in Nile tilapia (Oreochromis niloticus)     

Leaños-Castañeda O  Gold-Bouchot G  Van Der Kraak G  Lister A  Ceja-Moreno V  Simá-Alvarez R 《Marine environmental research》2004,58(2-5):337-342

The objective of this study was to determine if tamoxifen or an aromatase inhibitor (4-hydroxyandrostenedione; 4-OHA) affected plasma concentrations of o,p' -DDT and its metabolites, o,p'-DDD and o,p'-DDE, in mature tilapia. Male and female tilapia were injected 6 times intraperitoneally with o,p'-DDT (40 mg/kg) alone or in combination with 4-OHA (2 mg/kg) over a 12 day period. An additional group of male fish was injected with tamoxifen (5 mg/kg) plus o,p'-DDT. At the end of the treatment period, plasma samples were extracted and analyzed by GC/ECD. Females injected only with o,p'-DDT had significantly higher levels of o,p'-DDT compared with males. Interestingly, females and males treated concomitantly with o,p'-DDT and 4-OHA or tamoxifen had significantly lower concentrations of plasma o,p'-DDT (about 50%) compared with fish treated with only o,p'-DDT. These initial results suggest that an interaction between endocrine-active compounds occurs in vivo in tilapia and may involve alterations in metabolism of o,p'-DDT.  相似文献   

Interactive discovery of sequential patterns in time series of wind data     

Norhakim Yusof  Raul Zurita-Milla  Menno-Jan Kraak  Bas Retsios 《International journal of geographical information science》2016,30(8):1486-1506

Wind speed and direction vary over space and time due to the interactions between different pressures and temperature gradients within the atmospheric layers. Near the earth’s surface, these interactions are modulated by topography and artificial structures. Hence, characterizing wind behaviour over large areas and long periods is a complex but essential task for various energy-related applications. In this study, we present a novel approach to discover wind patterns by integrating sequential pattern mining and interactive visualization techniques. The approach relies on the use of the Linear time Closed pattern Miner sequence algorithm in conjunction with a time sliding window that allows the discovery of all sequential patterns present in the data. These patterns are then visualized using integrated 2D and 3D coordinated multiple views and visually explored to gain insight into the characteristics of the wind from a spatial, temporal and attribute (type of wind pattern) point of view. This proposed approach is used to analyse 10 years of hourly wind speed and direction data for 29 weather stations in the Netherlands. The results show that there are 15 main sequential patterns in the data. The spatial task shows that weather stations located in the same region do not necessarily experience similar wind pattern. For within the selected time interval, similar wind patterns can be observed in different stations and in the same station at different times of occurrence. The attribute task discovered that the repetitive occurrences of chosen pattern indicate as regular wind behaviour at different weather stations that persisted continuously over time. The results of these tasks show that the proposed interactive discovery facilitates the understanding of wind dynamics in space and time.  相似文献   

内蒙古鄂尔多斯高原古冰缘遗迹科学考察研究进展     

何瑞霞  金会军  蒋观利  张泽  陈雪梅  Raul David SERBAN  Mihaela SERBAN  Jef VANDENBERGHE  Valentin V.SPEKTOR  Hugh M.FRENCH 《冰川冻土》2021,43(1):263-273

冰缘遗迹（特别是冷生楔形构造及融冻褶皱）是重建古气候及第四纪晚期多年冻土环境的重要证据。内蒙古鄂尔多斯高原是我国北方地区冰缘现象最为发育的地区之一。为准确了解鄂尔多斯高原冰缘遗迹类型及其分布特征、区域冻土演化历史等,中国科学院西北生态环境资源研究院和荷兰自由大学共同组成科研小组,于2018年5—6月组织了“鄂尔多斯高原冰缘遗迹科学考察”。考察区域涉及靖边—城川—乌审旗—鄂尔多斯东胜区一带约12 000 km²的范围。考察内容主要包括鄂尔多斯高原冰缘遗迹类型及特征、分布区域、各类型冰缘遗迹所指示的气候条件的初步推断等。结果表明：冻融褶皱和冷生楔体构造是鄂尔多斯高原主要存在的两大类冰缘遗迹。基于本次考察中关于冰缘遗迹的分布与特征等新发现,并综合前人研究成果,初步推断：在气温极低、多年冻土非常发育的时段,有利于形成各类冷生楔状构造,如冰楔假形和大型原生砂楔等;在气候转暖、多年冻土退化,但还没有全部融化完阶段,可能形成融冻褶皱;区域性大面积分布和成群出现的融冻褶皱一般反映较暖气候环境下,多年冻土层上部已退化到一定程度。基于光释光（OSL）年代测试结果,结合冰缘遗迹的特征及其所指示的古气候环境,初步重建了鄂尔多斯5万年以来的冻土环境变化序列。区内多年冻土在多年冻土最大期（LPM,25~19 ka BP）时最发育,以大面积连续多年冻土为主;之后,随气温转暖,总趋势呈退化状态,多年冻土分布逐渐变为片状→岛状→零星斑状,直至现今全部融完变为深季节冻土区。  相似文献   

Effects of wave–current interaction on the current profile     

Maitane Olabarrieta  Raul Medina  Sonia Castanedo 《Coastal Engineering》2010

Wave–current laboratory experiments have shown that the logarithmic current profile observed in pure current flows is modified due to the presence of waves. When waves propagate opposite the current, an increase in the current intensity is achieved near the mean water level, while a reduction is obtained for following waves and currents. With the aim of analyzing these nonlinear effects along the whole water column, an Eulerian wave–current model is presented. In contrast to previously presented wave–current models, the present is able to include the variation of the free surface elevation due to the wave motion and the effect of a non hydrostatic pressure field. Therefore it does not restrict its application to waves in shallow waters. Moreover, the model is able to simulate all the possible angles between waves and currents.  相似文献   

Brazilian health regions and scales: A geographical perspective     

Raul Borges Guimarães 《New Zealand geographer》2007,63(2):97-105

Abstract:  This paper offers a geographical perspective on the way in which health regions have been defined and established in São Paulo as part of overall Brazilian health policy. To accomplish this, I first situate the Brazilian case in the international debate over the regionalization of health services. Second, I examine health regionalization in the case of São Paulo and show how the process is dynamic and complex, involving geographical scales that go well beyond the administrative boundaries of Brazilian municipalities.  相似文献   

Two-dimensional asymptotic iterative elastic inversion   总被引：3，自引：0，他引：3  

Side Jin  Raul Madariaga  Jean Virieux  Gilles Lambaré 《Geophysical Journal International》1992,108(2):575-588

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Gemini/GMOS spectra of globular clusters in the Leo group elliptical NGC 3379     

Michael Pierce  Michael A. Beasley  Duncan A. Forbes  Terry Bridges  Karl Gebhardt  Favio Raul Faifer  Juan Carlos Forte  Stephen E. Zepf  Ray Sharples  David A. Hanes  Robert Proctor 《Monthly notices of the Royal Astronomical Society》2006,366(4):1253-1264

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Galactosynthesis: halo histories, star formation and discs     

Ari Buchalter  Raul Jimenez  Marc Kamionkowski 《Monthly notices of the Royal Astronomical Society》2001,322(1):43-66

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Gemini/GMOS imaging of globular clusters in the Virgo galaxy NGC 4649 (M60)     

Duncan A. Forbes  Favio Raul Faifer  Juan Carlos Forte  Terry Bridges  Michael A. Beasley  Karl Gebhardt  David A. Hanes  Ray Sharples  Stephen E. Zepf 《Monthly notices of the Royal Astronomical Society》2004,355(2):608-616

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The inverse compton effect in the electrons of the Van Allen radiation belt     

Jorge Raul Albano 《Astrophysics and Space Science》1970,9(2):332-337

A first estimate of the energy that reaches the Earth's surface and is produced by the inverse Compton effect between the electrons in the Van Allen belt and the solar flux was made. Since in the belt there are electrons with energies between 0.5 and 7 MeV, it was possible to use the Klein-Nishina formula in an approximate form and estimate the energy that is Compton scattered by all the electrons in the Van Allen belt by using Vette, Lucero and Bright's model. The result was compared (a) with the measurements of the continuum in the regions of soft X-rays, and (b) with the energy that is produced by the trapped electrons through the synchrotron mechanism.This paper was presented at the COSPAR meeting held in leningrad on May 20–29, 1970.  相似文献